However, iron triggers the formation of free radicals via Fenton and Haber Weiss reactions during various metabolic activities [61,84] and presence of hesperidin before iron treatment might have blocked the generation of ironinduced free radicals resulting in the decline in iron-induced oxidative stress in the mice kidney
Sources of depletion can include: Mitochondrial energy production (a normal and essential process, but creates harmful byproducts like ROS) Chronic infections, gut dysbiosis (including SIBO and Candida ), and ongoing inflammation Air pollution, heavy metals, and environmental toxins 17 Ultra-processed foods, sugar-sweetened beverages, and foods high in advanced glycation end products (heavily browned foods) 18 Pesticides and herbicides 19 Alcohol and smoking Psychological stress Even vigorous exercise (a healthy stressor that still creates oxidative byproducts) 20 Understanding this helps explain why simply eating well sometimes isnt enough, and why targeted nutritional strategies make a meaningful difference
L-Glutathione may support healthy immune function, promote detoxification, and protect cells from oxidative stress
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That alone explains a lot of the variation in reported results
